Papworth Trust has announced it will not be taking any more referrals to its Workwise programme in Bury St Edmunds.
A statement from the disability charity said its Bury service had become unsustainable due to a drop in referral numbers.
But existing trainees will still be able to complete their programmes by the end of March.
Helena Harris, director of operations, said: “Papworth Trust took over the Workwise Centre in 2013 and has since invested more than £400,000 in the hope of making the programme sustainable.
“Unfortunately, the number of referrals to the Workwise programme has steadily declined to the point where the charity has taken the difficult decision to transfer resource to other services we provide for disabled people in Suffolk.
“The choice facing Papworth Trust was whether to continue to commit almost half a million pounds on a single service or use the same amount of money to provide approximately 50,000 hours of social care for disabled people throughout Suffolk and the whole of the East of England.
“In the coming months, we will continue to deliver a high level of support and training to our current placements until they complete their programmes at the end of March and we are working with Suffolk’s Mental Health Social Care Lead to support these trainees.
“For almost 100 years Papworth Trust has provided support for disabled people in the East of England and we remain as committed as ever to continuing this support with modern services that are fit for purpose.
“We would like to thank all the staff and volunteers who have worked hard to support our clients as well as the local community and local businesses who have provided work experience placements and other external support.