Police are appealing for witnesses to a serious collision on the A134 at Mundford.
It happened at around 7.20pm on Wednesday, close to the junction for West Tops.
Three cars, a black BMW, a blue Toyota and a DAF tanker, were involved in the collision.
The female driver of the Toyota was taken to hospital with serious injuries.
Anyone who may have witnessed the collision, or the manner of driving of the vehicles prior to the incident, should contact Pc Louise Manning at Swaffham Roads Policing on 101.